7 Things to know about Rejuran Healer in Korea

Image credit : AvenueL Clinic

Since it regenerates the skin cells themselves, it is very effective for treating acne scars and tightening the pores in your skin. It is also known for making your skin tone brighter and texture smoother.

Curious which skin concerns Rejuran can actually improve? See all 15 conditions it's commonly used for.

Because Rejuran went viral as a "salmon DNA" or "salmon sperm facial," expectations online are sometimes overblown. Setting realistic goals is the best way to feel happy with your results. Here's an honest breakdown of what a course of Rejuran Healer can and cannot do.

In short, Rejuran is a skin-quality and regeneration treatment, not a substitute for fillers, threads or surgery. For more complex concerns, many Korean clinics combine it with lasers or other boosters (see the comparison below).

(When more than 10 Nucleotides, which are in DNA, are linked together, it is called a PolyNucleotide)

PN is derived from and is a fragment of DNA, and extracted from Salmon milt. When this is injected into the skin, it works in the dermal layer helping the skin to regenerate. It increases its elasticity and reverses damages to skin. It is known to be a very safe substance, stable to heat and does not cause adverse side effects in the human body.

Ever wondered how K-pop idols achieve that "glass skin"? Discover how treatments like Rejuran fit into celebrity skincare routines.

The 'Salmon injection' is composed of PDRN, which like the PN is a fragment of DNA. But PN are typically longer threads than PDRN. So if the PDRN in Salmon injections act quickly in healing the skin structures, the PN in Rejuran Healer stays in the skin longer and acts as a support structure while healing.

If you've been researching skin boosters in Korea, you've likely come across both terms and they're easy to confuse. Here's a simple breakdown:

In short: PDRN works quickly to repair damaged tissue, while PN acts as a longer-lasting scaffold that supports ongoing skin regeneration. Neither is strictly "better" — the right choice depends on your skin goals. Many clinics in Korea combine both for a more comprehensive result.

"Rejuran" is a family of products by Pharmaresearch, each formulated for a different area and goal. Choosing the right one matters more than the price alone. Here's the 2026 line-up at a glance:

How does Rejuran fit among the wider "skin booster" category? If you're comparing PDRN/PN injectables to other popular boosters in Korea, this helps you see where each one sits:

Combining treatments: Many Seoul clinics pair Rejuran with another skin booster or a laser in the same plan for a more complete result — for example, some Jivaka listings offer a Rejuran + skin booster combination in one session. Just remember the caution from Section 7: avoid combining it on the same day as hyaluronic acid filler or fat injections, as this can trigger a hyper-reaction. Always disclose your full treatment history to your doctor.

• For those who do not want the unnatural look of getting fillers or botox, Rejuran Healer could be a good alternative
• For those in their 30s and above, with dry skin and frequent skin problems
• For those with wrinkles on the neck, around the eyes, and have stretch marks which are difficult to treat with other options
• For those with thinned or sensitive skin from overuse of laser treatment
• For those who want to make their skin naturally healthy

The Rejuran Healer injection can be injected in areas shown in the above image. For session, 2cc of injection is recommended. When used locally in small areas and with smaller amounts, it is said to be less effective. When injected in the forehead as well, 3cc of injection is recommended for each session. It can also be used for neck wrinkles, for which 2~4cc is injected evenly in the areas between the wrinkles.

Image credit : www.rejuran.com.sg

After 2~5 days, the skin becomes smoother and hydration level balanced.

After 2~4 weeks, skin becomes more elastic due to collagen generation, and light wrinkles and pores are reduced.

After a month, you will notice a natural lift and even a slight increase in volume.

The component properties of the Rejuran healer, compared to other cosmetic injectables like Hyaluronic acid fillers, Sculptra, and Ellanse, are more akin to our skin, so when injected as a standalone treatment it has almost no side effects. However you should be cautious when getting Rejuran healer with other treatments simultaneously. This is because when it comes into contact with hyaluronic acid or injected fat, it could cause hyper-reactions. To avoid this, you should consult with your doctor about your treatment history before getting Rejuran healers.

Rejuran is considered very safe for most people, but it isn't suitable for everyone. Tell your doctor your full medical history before booking. You should avoid or take special caution in the following situations:

A note on realistic expectations: Rejuran is a regenerative skin booster, not a miracle treatment. It does not replace fillers, threads or surgery, and individual results vary with age, skin condition and lifestyle. A licensed dermatologist or plastic surgeon — not a non-medical staff member — should assess whether it's right for you.

Authenticity matters (2026): The popularity of "salmon DNA" injections has created a grey market of refilled or generic products in some clinics. Ask to see genuine Pharmaresearch REJURAN® packaging and confirm the cc amount before your session. (More on choosing a clinic in Section 11.)

This is one of the most common questions from first-timers, and the honest answer is: it depends on your pain tolerance — but most patients find it very manageable.

What happens during the procedure:

• A topical numbing cream is applied 20–30 minutes before the injection
• The doctor uses a fine needle to make multiple micro-injections across the treatment area
• The entire session typically takes 30–45 minutes
• You may feel a mild stinging or pressure sensation, especially around thinner skin areas like under the eyes

After the procedure:

• Small bumps (papules) may appear at injection sites immediately after — this is completely normal and resolves within 24–48 hours
• Mild redness or swelling may last 1–3 days
• No significant downtime; most patients return to daily activities the same day
• Avoid saunas, intense exercise, and alcohol for 24–48 hours post-treatment

Section 8 covered the basics. Here's the part most guides skip: how much Rejuran "hurts" depends heavily on the needle, the device and the formula your clinic uses — so these are the questions worth asking before you book.

What actually changes your comfort level:

• Needle gauge (around 30–34G): the thinner the needle, the less you tend to feel each micro-injection.
• The HB formula contains lidocaine, which clinical reports suggest can meaningfully reduce injection pain compared with standard Rejuran Healer.
• The injection method itself — hand, device or cannula — makes a real difference, as shown below.

Injection method comparison:

Tip: If you bruise easily or are nervous about pain, ask your clinic which needle gauge and method they use, and whether the HB (lidocaine) option suits your treatment plan.

Results from Rejuran Healer are not permanent, but they are long-lasting compared to many other skin boosters.

• Initial effects (hydration, texture): visible within 1–2 weeks
• Peak results: around 4–8 weeks after the first session
• Duration of effects: typically 6–12 months, depending on age, lifestyle, and skin condition
• Recommended maintenance: most dermatologists suggest an initial course of 3 sessions spaced 3–4 weeks apart, followed by a maintenance session every 6–12 months

Keep in mind that younger patients with milder skin concerns tend to see longer-lasting results. Factors like sun exposure, smoking, and stress can shorten the duration of effects.

One of the biggest reasons patients travel to Korea for Rejuran Healer is the significantly lower price compared to other countries like Singapore, Japan, or the UK — often at the same or higher quality clinics.

Rejuran treatments available on Jivaka (based on current listings):

Prices are subject to change. Always confirm the exact cc amount and included services directly with the clinic.

👉 View all current Rejuran treatment options and prices on Jivaka

With hundreds of clinics offering Rejuran Healer in Seoul alone, choosing the right one can feel overwhelming. Here are key factors to consider:

✔ Verify the doctor's credentials
Rejuran should be performed by a licensed dermatologist or plastic surgeon — not a nurse or aesthetician. Ask who will be administering the injections.

✔ Check that they use authentic Pharmaresearch products
The original Rejuran Healer is made by Pharmaresearch Co., Ltd. Some clinics use cheaper alternatives. Ask to see the product packaging or look for "REJURAN®" on the label.

✔ Look for clinics with English support
If you're visiting Korea from abroad, having a clinic with English-speaking staff or medical coordinators makes a big difference for clear communication about your treatment history and goals.

✔ Transparent pricing = no surprise charges
A trustworthy clinic will clearly state the cc amount, product brand, and whether numbing cream is included in the quoted price.

✔ Check before & after photos and reviews
Look for real patient reviews on platforms like Naver, Gangnam Unni, or Google Maps. Clinics in Gangnam (especially around Apgujeong and Sinnonhyeon) tend to have high volumes of experience with international patients.

Can Rejuran Healer be combined with other treatments?
Yes — Rejuran Healer is often combined with laser treatments (e.g., Pico Laser, Fraxel), Botox, or other skin boosters for enhanced results. However, simultaneous use with hyaluronic acid fillers or fat injections on the same day should be done with caution, as it can trigger hyper-reactions. Always disclose your full treatment history to your doctor before the procedure.

Is Rejuran Healer safe for all skin types?
Generally yes. Because PN is biologically compatible with human skin, it is suitable for most skin types including sensitive skin. However, if you have a known allergy to fish or fish-derived products, consult your doctor before proceeding, as PN is extracted from salmon.

How is Rejuran Healer different from Profhilo or other skin boosters?
Profhilo is primarily a hyaluronic acid-based booster that works through hydration and bioremodelling. Rejuran Healer uses PN to directly regenerate skin cells and improve the skin's structural integrity at the dermal level. They target different mechanisms, and some patients choose to do both for complementary results.

Is there any downtime after Rejuran Healer?
Minimal. Small injection-site bumps (papules) typically resolve within 24–48 hours. Mild redness may last 1–3 days. Most patients look presentable within 1–2 days, making it a popular "weekend treatment" for those with busy schedules.

How many sessions do I need?
For first-time patients, a course of 3 sessions spaced 3–4 weeks apart is typically recommended to build up results. After that, 1 maintenance session every 6–12 months is usually sufficient to maintain the effects.

Can I get Rejuran Healer if I'm visiting Korea for a short time?
Yes. Many medical tourists get a single session during a short trip and experience noticeable improvements in skin texture and hydration. For optimal results, the recommended 3-session course is ideal — so many repeat visitors plan their trips around their treatment schedule.

Can I consult with a Korean dermatologist in English before visiting?
Absolutely. Jivaka offers free online derma consultations in English for international patients. Simply submit your photos and skin concerns, and a Korean dermatologist will assess your skin and recommend the most suitable treatments — before you even book your flight.